The major scientific breakthrough in recent years has been that human genome holds tiny microRNAs (micro-Ribonucleic Acids) in its exquisite readout-code and this phenomenon has revolutionized the way we look at the dynamic aspect of human genome in the human health and diseased states. It is in this context that the recent discovery of a novel microRNA (designated as miR-2909 in the international literature) by Prof. Deepak Kaul assumes importance. This microRNA has emerged not only to empower human immune T-cells to fight microbial infections but also may play a crucial role in evolution of autoimmune diseases as well as other degenerative diseases like Coronary Heart Disease and Cancer. Prof. Kaul’s research, at present, is directed to understand its impact as a double-edged sword in human health.
There exists a general recognition of the fact that about one-third of human genome encodes about 35000 genes. Historically, rest of the two-third human genome was considered to be a junk DNA which every human cell had in its fold. The major scientific breakthrough in recent years has been that this junk DNA encodes master-regulatory molecules known as microRNAs which have the inherent capacity to regulate all the 35000 genes responsible for human evolution. One such microRNA (designated as miR-2909 by Sanger’s miR-Base repository of microRNAs discovered across the globe) was discovered by Prof. Deepak Kaul for the first time in the year 2009 and subsequently this microRNA was shown by his research group to regulate genes involved in immunity as well as cancer and Coronary Heart Disease. It is in this context Prof. Kaul’s original research discovery assumes importance because this microRNA has the inherent capacity to act as a guardian of human genome through its ability to generate immune responses in order to equip our body to fight against various microbial infections as well as other auto-immune diseases. At present, extensive work is being carried out by his research group to unfold and understand the impact of this microRNA in human health in general and modulation of immune responses in particular.
Dr. Deepak KaulPh.D;FRCPath(Lond);FNA
Professor & Head
Experimental Medicine &BiotechnologyDepartment
P.G.I.M.E.R. ;Chandigarh-160012
M- 9872300606
The major scientific breakthrough in recent years has been that human genome holds tiny microRNAs (micro-Ribonucleic Acids) in its exquisite readout-code and this phenomenon has revolutionized the way we look at the dynamic aspect of human genome in the human health and diseased states. It is in this context that the recent discovery of a novel microRNA (designated as miR-2909 in the international literature) by Prof. Deepak Kaul assumes importance. This microRNA has emerged not only to empower human immune T-cells to fight microbial infections but also may play a crucial role in evolution of autoimmune diseases as well as other degenerative diseases like Coronary Heart Disease and Cancer. Prof. Kaul’s research, at present, is directed to understand its impact as a double-edged sword in human health.
There exists a general recognition of the fact that about one-third of human genome encodes about 35000 genes. Historically, rest of the two-third human genome was considered to be a junk DNA which every human cell had in its fold. The major scientific breakthrough in recent years has been that this junk DNA encodes master-regulatory molecules known as microRNAs which have the inherent capacity to regulate all the 35000 genes responsible for human evolution. One such microRNA (designated as miR-2909 by Sanger’s miR-Base repository of microRNAs discovered across the globe) was discovered by Prof. Deepak Kaul for the first time in the year 2009 and subsequently this microRNA was shown by his research group to regulate genes involved in immunity as well as cancer and Coronary Heart Disease. It is in this context Prof. Kaul’s original research discovery assumes importance because this microRNA has the inherent capacity to act as a guardian of human genome through its ability to generate immune responses in order to equip our body to fight against various microbial infections as well as other auto-immune diseases. At present, extensive work is being carried out by his research group to unfold and understand the impact of this microRNA in human health in general and modulation of immune responses in particular.
Dr. Deepak KaulPh.D;FRCPath(Lond);FNA
Professor & Head
Experimental Medicine &BiotechnologyDepartment
P.G.I.M.E.R. ;Chandigarh-160012
M- 9872300606